Pimethixene maleate is an antihistamine and antiserotonergic compound that acts as an antimigraine agent. It is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4, as well as muscarinic M1 and M2 receptors. The pKis for these receptors are 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61, and 9.38, respectively.
- Antihistamine and antiserotonergic compound.
- Acts as an antimigraine agent.
- Highly potent antagonist of multiple receptors including 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4, and muscarinic M1 and M2.
- For research use only.